abstract：:Recent physiological and pharmacological studies have implicated involvement of the Na/H exchanger (NHE) in regulating inner ear ion homeostasis, but the cellular distribution of this membrane transporter remains unknown. Here reverse transcription and the polymerase chain reaction (RT-PCR) were employed to screen adu...

journal_title：Hearing research

authors： Bond BR,Ng LL,Schulte BA

更新日期：1998-09-01 00:00:00

abstract：:The barn owl (Tyto alba) uses interaural level difference (ILD) as a cue for the localization of sound. The first site of binaural convergence in the pathway that processes ILD is the ventral lateral lemniscus pars posterior (VLVp). Neurons in VLVp receive excitatory input from the contralateral nucleus angularis, and...

journal_title：Hearing research

authors： Peddicord R

更新日期：1998-09-01 00:00:00

abstract：:Acoustic signals are extensively used for guiding various behaviors in frogs such as vocalization and phonotaxis. While numerous studies have investigated the anatomy and physiology of the auditory system, our knowledge of intrinsic properties and connectivity of individual auditory neurons remains poor. Moreover, the...

journal_title：Hearing research

authors： Luksch H,Walkowiak W

更新日期：1998-08-01 00:00:00

abstract：:Left ear noise-induced hearing losses are dominant in the army. The common explanation is the asymmetrical effect of the shooting posture. However, firm evidence to support this possibility is still lacking. In the French army shooters, eye preference rather than hand preference for shooting determines the side of sho...

journal_title：Hearing research

authors： Job A,Grateau P,Picard J

更新日期：1998-08-01 00:00:00

abstract：:Size and bilateral asymmetry (i.e. size difference between the left and the right hand side) of inner ear otoliths of larval mouthbreeding cichlid fish were determined during the ontogenetic development of larvae from hatching to the free swimming stage. Animals of two batches were raised in aquarium hatch baskets. Th...

journal_title：Hearing research

authors： Anken RH,Werner K,Ibsch M,Rahmann H

更新日期：1998-07-01 00:00:00

abstract：:In our companion paper (Le Calvez et al., 1998), the levels of distortion product otoacoustic emissions (DPOAE) were collected in the ears of CD1 mice with progressive degeneration of cochlear outer hair cells (OHC). Their comparison to standard functional measurements such as auditory-evoked brainstem responses (ABR)...

journal_title：Hearing research

authors： Le Calvez S,Guilhaume A,Romand R,Aran JM,Avan P

更新日期：1998-06-01 00:00:00

abstract：:The dorsal cochlear nucleus (DCN) has been shown to project to a region of the nucleus reticularis pontis caudalis (PnC) critical for the evocation of startle in rats, suggesting a possible modulatory influence of the DCN on startle. This study examined the involvement of the DCN in the acoustic startle reflex and var...

journal_title：Hearing research

authors： Meloni EG,Davis M

更新日期：1998-05-01 00:00:00

abstract：:In the cochlea, outer hair cells (OHCs) generate the active cochlear mechanics whereas the supporting cells, such as Deiters' cells and Hensen's cells, may play a role in both the active and passive cochlear mechanics. The presence of receptors for adenosine triphosphate (ATP) on OHCs, Deiters' cells and Hensen's cell...

journal_title：Hearing research

authors： Chen C,Skellett RA,Fallon M,Bobbin RP

更新日期：1998-04-01 00:00:00

abstract：:We have studied the noradrenergic and serotonergic changes induced by white noise stimulation at 70, 90 or 110 dB SPL for 45 min, in cochlear nuclei, inferior colliculus (IC), primary auditory cortex (PAC) and as a comparison in locus coeruleus (LC) and raphe dorsalis using HPLC. Both noradrenergic and serotonergic pa...

journal_title：Hearing research

authors： Cransac H,Cottet-Emard JM,Hellström S,Peyrin L

更新日期：1998-04-01 00:00:00

abstract：:Auditory brainstem responses (ABRs) were evoked in developing wallabies by click and tone burst stimuli delivered by bone conduction and air conduction, at progressive stages of post-natal (pouch) life. ABRs were recorded through the onset of auditory responses (95-110 days), the opening of the external ear canal (125...

journal_title：Hearing research

authors： Hill KG,Cone-Wesson B,Liu GB

更新日期：1998-03-01 00:00:00

abstract：:Most investigators place reflective beads on the basilar membrane to measure its vibration with optical methods. It is therefore important to find out if the beads faithfully follow the motion of the structures on which they are placed. Vibration of the beads on the basilar membrane and basilar membrane adjacent to th...

journal_title：Hearing research

authors： Khanna SM,Ulfendahl M,Steele CR

更新日期：1998-02-01 00:00:00

abstract：:There is increasing evidence to suggest that free radical generation is central to a variety of pathological processes, including drug toxicity. Studies demonstrating the ability of gentamicin to facilitate the generation of radical species suggest that this process plays an important role in aminoglycoside-induced ot...

journal_title：Hearing research

authors： Conlon BJ,Smith DW

更新日期：1998-01-01 00:00:00

abstract：:We developed a new technique, the isolated in vitro perfused spiral modiolar artery, which allowed the continuous measurement of the vascular diameter and control of the intravascular pressure. An isolated section of the spiral modiolar artery from the gerbil was perfused on one end with a set of concentric pipettes a...

journal_title：Hearing research

authors： Wangemann P,Gruber DD

更新日期：1998-01-01 00:00:00

abstract：:Although pulmonary infections caused by Pseudomonas aeruginosa can hardly be eradicated in patients with cystic fibrosis (CF, the most common genetic disease among Caucasians), these patients are mainly treated with intravenous and nebulized tobramycin. Long-term treatment with tobramycin, however, may induce ototoxic...

journal_title：Hearing research

authors： Sone M,Schachern PA,Paparella MM

更新日期：1998-01-01 00:00:00

abstract：:Strial marginal cells are known to take up and metabolize glucose as their main source of metabolic energy. The membrane transport mechanisms for glucose uptake into strial marginal cells, however, are largely unknown. Two types of glucose transporters in mammalian cells have been described, the facilitated glucose tr...

journal_title：Hearing research

authors： Takeuchi S,Ando M

更新日期：1997-12-01 00:00:00

abstract：:Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sod...

journal_title：Hearing research

authors： Ruan RS,Leong SK,Yeoh KH

更新日期：1997-12-01 00:00:00

abstract：:To rehabilitate profoundly deaf patients who are not suitable for cochlear implants, central auditory prostheses have been implanted. To compare two possible electrode configurations - penetrating and surface ones - electrical stimulation of the cochlear nucleus with both types of arrays was tested on guinea pigs and ...

journal_title：Hearing research

authors： Liu X,McPhee G,Seldon HL,Clark GM

更新日期：1997-12-01 00:00:00

abstract：:Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulation frequencies for 251...

journal_title：Hearing research

authors： Kenmochi M,Eggermont JJ

更新日期：1997-11-01 00:00:00

abstract：:Both sound exposure and gentamicin treatment cause damage to sensory hair cells in the peripheral chick auditory organ, the basilar papilla. This induces a regeneration response which replaces hair cells and restores auditory function. Since functional recovery requires the re-establishment of connections between rege...

journal_title：Hearing research

authors： Ofsie MS,Hennig AK,Messana EP,Cotanche DA

更新日期：1997-11-01 00:00:00

abstract：:Neural auditory thresholds in the guinea pig can be temporarily improved by up to 6 dB about 2 min after the cessation of an moderately intense low-frequency tone (Kirk and Patuzzi, 1997). We have measured changes in the f2-f1 distortion product otoacoustic emission (DPOAE) and low-frequency microphonic potential in s...

journal_title：Hearing research

authors： Kirk DL,Moleirinho A,Patuzzi RB

更新日期：1997-10-01 00:00:00

abstract：:The columnar and layer-specific response properties of neurons in the primary auditory cortex (AI) of Mongolian gerbils were studied using single-unit recordings of responses to tone-burst stimuli presented to the ear contralateral to the recording side. During near-radial microelectrode penetrations of the AI in 100-...

journal_title：Hearing research

authors： Sugimoto S,Sakurada M,Horikawa J,Taniguchi I

更新日期：1997-10-01 00:00:00

abstract：:In the cochlea, outer hair cells (OHCs) and Deiters' cells most likely contribute to the generation of active cochlear mechanics. The presence of ATP receptors on these cells indicates that endogenous ATP may have a role in cochlear mechanics. To explore this possibility, the effects of ATP antagonists were studied bo...

journal_title：Hearing research

authors： Skellett RA,Chen C,Fallon M,Nenov AP,Bobbin RP

更新日期：1997-09-01 00:00:00

abstract：:In a previous study, we have demonstrated the presence of two adenosine receptor (AR) subtypes, namely A1 and A3AR, in the chinchilla cochlea. One or both of these receptors couple to activation of antioxidant enzymes, with resulting decreases in lipid peroxidation. The chemotherapeutic agent, cisplatin, was shown to ...

journal_title：Hearing research

authors： Ford MS,Nie Z,Whitworth C,Rybak LP,Ramkumar V

更新日期：1997-09-01 00:00:00

abstract：:Biochemical and pharmacological evidence support a role for nitric oxide (NO) and glutathione (GSH) in the cochlea. GSH combines with NO in tissue to form nitrosoglutathione (GSNO) that can act as a storage form for GSH and NO. Therefore, we tested GSNO on sound-evoked responses of the cochlea (cochlear microphonic, C...

journal_title：Hearing research

authors： Nenov AP,Skellett RA,Fallon M,Bobbin RP

更新日期：1997-08-01 00:00:00

abstract：:A hyperpolarization-activated current (termed I[h]) is believed to provide a pacemaker depolarization in sinoatrial node cells and in some central and peripheral neurons. In the present study, we examined if such an inward cation current exists in primary auditory neurons using the whole-cell patch-clamp technique. A ...

journal_title：Hearing research

authors： Chen C

更新日期：1997-08-01 00:00:00

abstract：:In spontaneously active neurons in the external nucleus of the inferior colliculus of the barn owl, a stimulus-driven discharge was followed by a quiescent period lasting tens of milliseconds before the spontaneous activity resumed. The more favorable the interaural time difference, the longer the quiet period. The du...

journal_title：Hearing research

authors： Albeck Y

更新日期：1997-07-01 00:00:00

abstract：:It is known that the threshold of an acoustically induced middle-ear-muscle (MEM) reflex can be lowered by the simultaneous presentation of a second tone (facilitator), which is presented to the ipsilateral or contralateral ear at a level below the acoustic reflex threshold (ART) of the facilitator itself (Sesterhenn ...

journal_title：Hearing research

authors： Kawase T,Hidaka H,Takasaka T

更新日期：1997-06-01 00:00:00

abstract：:The tension fibroblasts of the spiral ligament of the mammalian cochlea are thought to create radial tension on the basilar membrane. Their postnatal development was investigated in the gerbil (Meriones unguiculatus) with confocal fluorescence microscopy using phallotoxin as a specific marker for F-actin. In the adult...

journal_title：Hearing research

authors： Kuhn B,Vater M

更新日期：1997-06-01 00:00:00

abstract：:The IgG1 mouse monoclonal antibody (MAb) KHRI-3, binds to an antigen of 65-68 kDa expressed on inner ear supporting cells in guinea pigs. We previously showed [Nair et al. (1995) Monoclonal antibody induced hearing loss. Hear. Res. 83, 101-113] that mice carrying the KHRI-3 hybridoma develop high frequency hearing los...

journal_title：Hearing research

authors： Nair TS,Prieskorn DM,Miller JM,Mori A,Gray J,Carey TE

更新日期：1997-05-01 00:00:00

abstract：:A small, acidic Ca(2+)-binding protein (CBP-15) was recently detected in extracts of the mammalian auditory receptor organ, the organ of Corti [Senarita et al. (1995) Hear. Res. 90, 169-175]. N-terminal sequence data for CBP-15 [Thalmann et al. (1995) Biochem. Biophys. Res. Commun. 215, 142-147] implied membership in ...

journal_title：Hearing research

authors： Henzl MT,Shibasaki O,Comegys TH,Thalmann I,Thalmann R

更新日期：1997-04-01 00:00:00

abstract：:Previous studies indicate the presence of adenosine receptors in the cochlear tissues obtained from different animals. This study was initiated to determine the subtypes of adenosine receptor (AR) present in the chinchilla cochlea and to assess their function. Radioligand binding studies demonstrate the presence of bo...

journal_title：Hearing research

authors： Ford MS,Maggirwar SB,Rybak LP,Whitworth C,Ramkumar V

更新日期：1997-03-01 00:00:00

abstract：:In response to low-intensity, low-frequency, phase-locked tonal stimuli with non-alternating polarity, the time-average round window (RW) response of the gerbil is a mixture of the auditory nerve neurophonic (ANN) and cochlear microphonic (CM), with the former often being of equal or greater magnitude than the latter....

journal_title：Hearing research

authors： Henry KR

更新日期：1997-02-01 00:00:00

abstract：:The influence of an external tone on transitory evoked otoacoustic emissions (TEOAE) is investigated. Three different averaging techniques were used with the same acoustic stimulus paradigm. These techniques permitted the separation of those parts of the otoacoustic emission (OAE) that contribute to the transitory evo...

journal_title：Hearing research

authors： Neumann J,Uppenkamp S,Kollmeier B

更新日期：1997-01-01 00:00:00

abstract：:Polyclonal antibodies were raised in chickens to the glycosylated forms of the high (H), medium (M) and low (L) molecular mass (MM) mouse tectorins. In the mouse cochlea, all three antibodies stained the tectorial membrane. Antibodies raised to HMM tectorin also stained the hair bundles of both inner and outer hair ce...

journal_title：Hearing research

authors： Killick R,Richardson GP

更新日期：1997-01-01 00:00:00

abstract：:The gravity-sensing organ of Aplysia californica consists of bilaterally paired statocysts containing statoconia, which are granules composed of calcium carbonate crystals in an organic matrix. In early embryonic development, Aplysia contain a single granule called a statolith, and as the animal matures, statoconia pr...

journal_title：Hearing research

authors： Pedrozo HA,Schwartz Z,Luther M,Dean DD,Boyan BD,Wiederhold ML

更新日期：1996-12-01 00:00:00

abstract：:The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Respons...

journal_title：Hearing research

authors： Boettcher FA,Mills JH,Swerdloff JL,Holley BL

更新日期：1996-12-01 00:00:00

abstract：:Single neuron responses to sinusoidal 20 Hz amplitude modulated tone bursts (612.5 ms stimulus-on time at the rate of once per 2.2 s) were studied in the auditory midbrain (torus semicircularis) of the immobilized grass frog (Rana temporaria temporaria). The characteristic frequency stimuli at 30 dB above the minimum ...

journal_title：Hearing research

authors： Bibikov NG,Nizamov SV

更新日期：1996-11-01 00:00:00

abstract：:The properties of the ACh (acetylcholine) response in guinea pig outer hair cells (OHCs) are not well understood. It has been shown that the response to ACh involves the activation of a Ca2+ dependent K+ selective conductance (referred to as Ksub where sub stands for suberyldicholine). In the present study, we examine...

journal_title：Hearing research

authors： Nenov AP,Norris C,Bobbin RP

更新日期：1996-11-01 00:00:00

abstract：:The inferior colliculus (IC) is one nucleus of the central auditory system which displays age-related changes. Inputs to the IC use primarily the amino acid neurotransmitters glutamate and gamma-aminobutryic acid (GABA). Neurochemical and anatomical studies of the Fischer 344 (F344) rat IC have shown decreases in GABA...

journal_title：Hearing research

authors： Palombi PS,Caspary DM

更新日期：1996-10-01 00:00:00

abstract：:Using single-unit electrophysiological methods we have mapped sound frequency (or cochleotopic) representation in the auditory cortex of the chinchilla. We describe the surgical approach to expose this area. We report on maps from six subjects and note a considerable variation in shape between individuals. In general,...

journal_title：Hearing research

authors： Harrison RV,Kakigi A,Hirakawa H,Harel N,Mount RJ

更新日期：1996-10-01 00:00:00